Mutation rates at Y chromosome specific microsatellites

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Gusmao, L (Author) Other; Sanchez Diz, P (Author) Other; Calafell, F (Author) Other; Martin, P (Author) Other; Alonso, CA (Author) Other; Alvarez Fernandez, F (Author) Other; Alves, C (Author) Other; Borjas Fajardo, L (Author) Other; Bozzo, WR (Author) Other; Bravo, ML (Author) Other; Builes, JJ (Author) Other; Capilla, J (Author) Other; Carvalho, M (Author) Other; Castillo, C (Author) Other; Catanesi, CI (Author) Other; Corach, D (Author) Other; Di Lonardo, AM (Author) Other; Espinheira, R (Author) Other; de Carvalho, EF (Author) Other; Farfan, MJ (Author) Other; Figueiredo, HP (Author) Other; Gomes, I (Author) Other; Lojo, MM (Author) Other; Marino, M (Author) Other; Pinheiro, ME (Author) Other; Pontes, ML (Author) Other; Prieto, V (Author) Other; Ramos Luis, E (Author) Other; Riancho, JA (Author) Other; Goes, ACS (Author) Other; Santapa, OA (Author) Other; Sumita, DR (Author) Other; Vallejo, G (Author) Other; Rioja, LV (Author) Other; Vide, MC (Author) Other; da Silva, CIV (Author) Other; Whittle, MR (Author) Other; Zabala, W (Author) Other; Zarrabeitia, MT (Author) Other; Alonso, A (Author) Other; Carracedo, A (Author) Other; Amorim, A (Author) FCUP

Journal

Title: Human Mutation

Vol. 26

Pages: 520-528

ISSN: 1059-7794

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 119 Citations

Scopus - 124 Citations

Scientific classification

FOS: Natural sciences > Earth and related Environmental sciences

Other information

Authenticus ID: P-000-07Q

DOI: 10.1002/humu.20254

Abstract (EN): A collaborative work was carried out by the Spanish and Portuguese ISFG Working Group (GEP-ISFG) to estimate Y-STR mutation rates. Seventeen Y chromosome STR loci (DYS19, DYS385, DYS389I and 11, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS460, DYS461, DYS635 [GATA C4], GATA H4, and GATA A10) were analyzed in a sample of 3,026 father/son pairs. Among 27,029 allele transfers, 54 mutations were observed, with an overall mutation rate across the 17 loci of 1.998 x 10(-3) (95% Cl, 1.501 X 10(-3) to 2.606 x 10(-3)). With just one exception, all of the mutations were single-step, and they were observed only once per gametogenesis. Repeat gains were more frequent than losses, longer alleles were found to be more mutable, and the mutation rate seemed to increase with the father's age. Hum Mutat 26(6), 520-528, 2005. (c) 2005 Wiley-Liss, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9