X-chromosome markers in kinship testing: A generalisation of the IBD approach identifying situations where their contribution is crucial

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Nadia Pinto (Author) Other; Leonor Gusmao (Author) Other; Antonio Amorim (Author) FCUP

Journal

Title: Forensic Science International: Genetics

Vol. 5

Pages: 27-32

ISSN: 1872-4973

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 54 Citations

Scopus - 65 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-002-YKW

DOI: 10.1016/j.fsigen.2010.01.011

Abstract (EN): The standard practice of forensic kinship evaluation uses unlinked autosomal markers. However, X-chromosome markers have recently gained recognition as a powerful tool to complement the information provided by autosomes, particularly in complex cases. In this paper, the X-chromosome mode of transmission is addressed in the theoretical identity-by-descent framework. Formulas for the joint genotypic probabilities considering various pedigrees relating two inbred and/or non-inbred individuals are derived. Finally, the importance of X-chromosome markers is highlighted by the fact that, in addition to complementing the autosomal information, X-chromosome transmission allows differential weighting of certain hypotheses regarding pedigrees belonging to the same autosomal class, i.e., pedigrees that are indistinguishable by the use of unlinked autosomal markers. Illustrative examples of common kinship testing are shown.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6