mtDNA phylogeny and evolution of laboratory mouse strains

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Ana Goios (Author) Other; Luisa Pereira (Author) Other; Molly Bogue (Author) Other; Vincent Macaulay (Author) Other; Antonio Amorim (Author) FCUP

Journal

Title: Genome Research

Vol. 17

Pages: 293-298

ISSN: 1088-9051

Publisher: Cold Spring Harbor Laboratory Press

Indexing

ISI Web of Knowledge - 82 Citations

Scopus - 84 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-004-BF0

DOI: 10.1101/gr.5941007

Abstract (EN): Inbred mouse strains have been maintained for more than 100 years, and they are thought to be a mixture of four different mouse subspecies. Although genealogies have been established, female inbred mouse phylogenies remain unexplored. By a phylogenetic analysis of newly generated complete mitochondrial DNA sequence data in 16 strains, we show here that all common inbred strains descend from the same Mus musculus domesticus female wild ancestor, and suggest that they present a different mitochondrial evolutionary process than their wild relatives with a faster accumulation of replacement substitutions. Our data complement forthcoming results on resequencing of a group of priority strains, and they follow recent efforts of the Mouse Phenome Project to collect and make publicly available information on various strains.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6