Antitumor Activity of Hierridin B, a Cyanobacterial Secondary Metabolite Found in both Filamentous and Unicellular Marine Strains

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Pedro N Leão (Author) Other; Margarida Costa (Author) Other; Vitor Ramos (Author) Other; Alban R Pereira (Author) Other; Virgínia C Fernandes (Author) Other; Valentina F Domingues (Author) Other; William H Gerwick (Author) Other; Vitor M Vasconcelos (Author) Other; Rosário Martins (Author) Other

Journal

Title: PLoS ONE

Vol. 8 No. 1

Final page: e69562

ISSN: 1932-6203

Publisher: Public Library of Science

Indexing

ISI Web of Knowledge - 42 Citations

Scopus - 49 Citations

Other information

Authenticus ID: P-006-933

DOI: 10.1371/journal.pone.0069562

Abstract (EN): Cyanobacteria are widely recognized as a valuable source of bioactive metabolites. The majority of such compounds have been isolated from so-called complex cyanobacteria, such as filamentous or colonial forms, which usually display a larger number of biosynthetic gene clusters in their genomes, when compared to free-living unicellular forms. Nevertheless, picocyanobacteria are also known to have potential to produce bioactive natural products. Here, we report the isolation of hierridin B from the marine picocyanobacterium Cyanobium sp. LEGE 06113. This compound had previously been isolated from the filamentous epiphytic cyanobacterium Phormidium ectocarpi SAG 60.90, and had been shown to possess antiplasmodial activity. A phylogenetic analysis of the 16S rRNA gene from both strains confirmed that these cyanobacteria derive from different evolutionary lineages. We further investigated the biological activity of hierridin B, and tested its cytotoxicity towards a panel of human cancer cell lines; it showed selective cytotoxicity towards HT-29 colon adenocarcinoma cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8