Antimicrobial and cytotoxic assessment of marine cyanobacteria - Synechocystis and synechococcus

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Rosario F Martins (Author) Other; Miguel F Ramos (Author) Other; Lars Herfindal (Author) Other; Jose A Sousa (Author) FCUP; Kaja Skaerven (Author) Other; Vitor M Vasconcelos (Author) FCUP

Journal

Title: Marine Drugs

Vol. 6

Pages: 1-11

ISSN: 1660-3397

Publisher: MDPI

Indexing

ISI Web of Knowledge - 91 Citations

Scopus - 98 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-004-19E

Abstract (EN): Aqueous extracts and organic solvent extracts of isolated marine cyanobacteria strains were tested for antimicrobial activity against a fungus, Gram-positive and Gram-negative bacteria and for cytotoxic activity against primary rat hepatocytes and HL-60 cells. Antimicrobial activity was based on the agar diffusion assay. Cytotoxic activity was measured by apoptotic cell death scored by cell surface evaluation and nuclear morphology. A high percentage of apoptotic cells were observed for HL-60 cells when treated with cyanobacterial organic extracts. Slight apoptotic effects were observed in primary rat hepatocytes when exposed to aqueous cyanobacterial extracts. Nine cyanobacteria strains were found to have antibiotic activity against two Gram-positive bacteria, Clavibacter michiganensis subsp. insidiosum and Cellulomonas uda. No inhibitory effects were found against the fungus Candida albicans and Gram-negative bacteria. Marine Synechocystis and Synechococcus extracts induce apoptosis in eukaryotic cells and cause inhibition of Gram-positive bacteria. The different activity in different extracts suggests different compounds with different polarities.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11