Atrial natriuretic peptides and renin release

• Type: Article in International Scientific Journal
• Date: 1988

Authors

Richards, AM (Author) Other; Tonolo, G (Author) Other; Tree, M (Author) Other; Robertson, JIS (Author) Other; Montorsi, P (Author) Other; Leckie, BJ (Author) Other; Polonia, J (Author) FMUP

Journal

Title: The American Journal of Medicine

Vol. 84

Pages: 112-118

ISSN: 0002-9343

Publisher: Elsevier

Indexing

ISI Web of Knowledge

Scopus - 38 Citations

Other information

Authenticus ID: P-008-PW5

DOI: 10.1016/0002-9343(88)90214-8

Abstract (EN): The relationship between endogenous plasma concentrations of atrial natriuretic peptide and renin was examined in resting normal subjects and patients with cardiac impairment. To test the hypothesis that atrial natriuretic peptide inhibits renin secretion, intravenous infusions of atrial natriuretic peptide were administered to normal volunteers, patients with end-stage renal failure, and conscious dogs in both sodium-replete and sodium-depleted states. Plasma atrial natriuretic peptide and renin were inversely related in normal subjects (r = -0.52, n = 140, p <0.001), but a weak positive association between these two variables was observed in patients with cardiac impairment (r = 0.32, n = 60, p <0.02). Low doses of both 26- and 28-amino-acid human atrial natriuretic peptide (2 pmol/kg/minute for two hours) given to sodium-replete normal subjects halved plasma renin compared with time-matched placebo values (19 ± 4 and 18 ± 3 versus 36 ± 8 ¿U/ml, p <0.001 for both). Incremental doses of synthetic atrial natriuretic peptide suppressed plasma renin below time-matched placebo values in both sodium-replete (maximal suppression 1.2 ± 0.4 versus 8.6 ± 1.4 ¿U/ml, p <0.001) and sodium-depleted (maximal suppression 18.9 ± 4.9 versus 51 ± 13 ¿U/ml, p <0.05) dogs. This effect was initially apparent at low doses of atrial natriuretic peptide (1 pmol/kg/minute), and renin suppression was maximal, in both states, with lesser doses of atrial natriuretic peptide than those at which maximal natriuresis was observed. Atrial natriuretic peptide administered to patients with end-stage renal failure (10 pmol/kg/minute for one hour) caused no change in plasma renin. These data confirm that atrial natriuretic peptide inhibits renin secretion in a dose-related manner and suggest that this action of the peptide is modified by both the baseline sodium status and renal function of the recipient. © 1988.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7