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SYMPATHETIC DENERVATION CAUSES ATRIAL NATRIURETIC PEPTIDE-STORING GRANULES TO APPEAR IN THE VENTRICULAR MYOCARDIUM OF THE RAT

Title
SYMPATHETIC DENERVATION CAUSES ATRIAL NATRIURETIC PEPTIDE-STORING GRANULES TO APPEAR IN THE VENTRICULAR MYOCARDIUM OF THE RAT
Type
Another Publication in an International Scientific Journal
Year
1990
Authors
Albino Teixeira, A
(Author)
FMUP
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POLONIA, JJ
(Author)
FMUP
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AZEVEDO, I
(Author)
Other
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Journal
Vol. 342
Pages: 241-244
ISSN: 0028-1298
Publisher: Springer Nature
Scientific classification
FOS: Medical and Health sciences > Basic medicine
Other information
Authenticus ID: P-001-RMC
Abstract (EN): Sympathetic denervation of the rat heart was produced by 6-hydroxydopamine. In denervated ventricles abundant "atrial" granules were observed whereas in controls no such granules were seen. Denervated ventricles and atria showed a very high content of atrial natriuretic peptide-like immunoreactivity (> 10 times higher than in control animals). We suggest that the sympathetic nervous system exerts a repressive effect upon synthesis of atrial natriuretic peptide-like material and upon the formation of atrial natriuretic peptide-storing granules in the ventricular myocardium. © 1990 Springer-Verlag.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 4
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