Abstract (EN):
Sympathetic denervation of the rat heart was produced by 6-hydroxydopamine. In denervated ventricles abundant "atrial" granules were observed whereas in controls no such granules were seen. Denervated ventricles and atria showed a very high content of atrial natriuretic peptide-like immunoreactivity (> 10 times higher than in control animals). We suggest that the sympathetic nervous system exerts a repressive effect upon synthesis of atrial natriuretic peptide-like material and upon the formation of atrial natriuretic peptide-storing granules in the ventricular myocardium. © 1990 Springer-Verlag.
Language:
English
Type (Professor's evaluation):
Scientific
No. of pages:
4