ENZYME-INHIBITION AS VISUALIZED WITH THE RESERVOIR MODEL - RELATIONSHIPS BETWEEN I-50 AND INHIBITION CONSTANT(S) OF AN ENZYME-INHIBITOR

• Type: Article in International Scientific Journal
• Date: 1994

Authors

ribeiro, jm (Author) Other; fontes, r (Author) FMUP; sillero, a (Author) Other

Journal

Title: Computers in Biology and Medicine

Vol. 24

Pages: 129-144

ISSN: 0010-4825

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 5 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-001-KAQ

DOI: 10.1016/0010-4825(94)90071-x

Abstract (EN): In the reservoir model, enzyme activity is simulated by holes in the wall of a reservoir (metabolic pool) containing liquid (substrate) at a certain level (concentration). The holes are computer drawn to reflect the kinetic properties of the enzyme, namely its maximum velocity (hole area) and K, (hole position). The model is here presented as a tool to intuitively visualize the effect of the different types of reversible enzyme inhibitors on the kinetic properties of an enzyme. The relationships between the concentration of an inhibitor producing 50% inhibition of an enzyme reaction (I-50) and its inhibition constant(s) are also discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16