Response of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise programme in older men and women

• Type: Article in International Scientific Journal
• Date: 2013

Authors

marques, ea (Author) Other; mota, j (Author) FADEUP; viana, jl (Author) Other; tuna, d (Author) Other; figueiredo, p (Author) Other; guimaraes, jt (Author) FCNAUP; carvalho, j (Author) FADEUP

Journal

Title: Archives of Gerontology and Geriatrics

Vol. 57

Pages: 226-233

ISSN: 0167-4943

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 41 Citations

Scopus - 54 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-006-826

DOI: 10.1016/j.archger.2013.03.014

Abstract (EN): This study examines the effects of 32 weeks of exercise training on balance, lower-extremity muscle strength, bone mineral density (BMD) and serum levels of bone metabolism and inflammatory markers in older adults. Forty-seven healthy older adults (women = 24, men = 23; mean age 68.2 years) participated in a exercise intervention (60 min/session) that included resistance exercise training (2 days/week) at 75-80% of maximum plus a multicomponent weight-bearing impact exercise training (1 day/week). Outcome measures included lumbar spine and proximal femoral BMD, dynamic balance, muscle strength, serum levels of bone metabolism markers [osteocalcin (OC), C-terminal telopeptide of Type I collagen (CTX), osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL)] and serum levels of inflammatory markers [high sensitive (hs)-C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma]. Potential confounding variables included body composition, dietary intake (using 4-day diet records), and accelerometer-based physical activity. After 32 weeks, both men and women increased dynamic balance (6.4%), muscle strength (11.0%) and trochanter (0.7%), intertrochanter (0.7%), total hip (0.6%), and lumbar spine BMD (1.7%), while OC, CTX, OPG and RANKL levels remained unchanged. In addition, hs-CRP and IFN-gamma levels were decreased, while TNF-alpha levels were unchanged, and a decrease in IL-6 levels was only observed in men. These findings suggest that our combined impact protocol reduces inflammation and increases BMD, balance, and lower-extremity muscle strength, despite having little effect on bone metabolism markers. This reinforces the role of exercise to counteract the age-related inflammation, and the muscle strength, balance and BMD reduction.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8