Influence of maturation and ageing on the biotransformation of noradrenaline in the rat

• Type: Article in International Scientific Journal
• Date: 1998

Authors

guimaraes, jt (Author) FMUP; paiva, mq (Author) Other; moura, d (Author) REIT; guimaraes, s (Author) Other

Journal

Title: Journal of Neural Transmission, Supplement

Pages: 225-232

ISSN: 0303-6995

Publisher: Springer

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 4 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-001-9CD

Abstract (EN): The present investigation was undertaken to study the influence of maturation and ageing on the disposition of noradrenaline by the aorta, heart (ventricle), liver and kidney of the rat. Slices of these tissues taken from rats aged less than 18h, 2.5-3 months or 18-24, months were incubated with 0.1 mu mol.l(-1) (3)H-amine during 30min. At the end of this period, the accumulation of the intact amine in the tissue, as well as the (3)H-metabolites formed (3,4-dihydroxyphenylethylglycol, 3,4-dihydroxymandelic acid, normetanephrine and O-methylated deaminated metabolites) were determined by scintillation counting. The results obtained show that in the rat: 1) at any age, noradrenaline is preferentially deaminated; 2) while the capacity of the sympathetic nerve terminals in accumulating noradrenaline is rather well developed at birth. the metabolic system for its degradation is still immature 3) aldehyde dehydrogenase activity or that of its co-factor (or both) of the heart is apparently missing at birth; 4) removal of noradrenaline by the liver and the kidney did not change with ageing, while that by the aorta decreased and that by the heart increased.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8