Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis of Type 1 Cardio-Renal Syndrome in the General Ward

• Type: Article in International Scientific Journal
• Date: 2011

Authors

alvelos, m (Author) Other; pimentel, r (Author) Other; pinho, e (Author) Other; gomes, a (Author) Other; lourenco, p (Author) Other; teles, mj (Author) Other; almeida, p (Author) Other; guimaraes, jt (Author) FMUP; bettencourt, p (Author) FMUP

Journal

Title: Clinical journal of the American Society of Nephrology : CJASN

Vol. 6

Pages: 476-481

ISSN: 1555-9041

Publisher: American Society of Nephrology

Indexing

ISI Web of Knowledge - 82 Citations

Scopus - 83 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-002-TXJ

DOI: 10.2215/cjn.06140710

Abstract (EN): Background and objectives The early identification of acute heart failure (HF) patients with type 1 cardiorenal syndrome should be the first step for developing prevention and treatment strategies for these patients. This study aimed to assess the performance of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C in the early detection of type 1 cardio-renal syndrome in patients with acute HF. Design, setting, participants, & measurements One-hundred nineteen patients admitted with acute HF were studied. NGAL and creatinine were measured in the first hospitalization morning; creatinine was also measured at least after 48 to 72 hours. Physicians were blinded to NGAL and cystatin C levels. Type 1 cardio-renal syndrome was defined as an increase in the creatinine level of at least 0.3 mg/dl or 50% of basal creatinine. Results Type 1 cardio-renal syndrome developed within 48 to 72 hours in 14 patients (11.8%). Admission NGAL levels were higher in these patients: 212 versus 83 ng/dl. At a cutoff value of 170 ng/L, NGAL determined type 1 cardio-renal syndrome with a sensitivity of 100% and a specificity of 86.7%. The area under the receiver-operating characteristic curve of NGAL was 0.93 and that of cystatin C was 0.68. Conclusions Above a cutoff value of 170 ng/L, NGAL predicts 48- to 72-hour development of type 1 cardiorenal syndrome with a negative predictive value of 100% and a positive predictive value of 50%. NGAL independently associates with type 1 cardio-renal syndrome and might be a useful biomarker in the early recognition of these patients. Clin J Am Soc Nephrol 6: 476-481, 2011. doi: 10.2215/CJN.06140710

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6