Urinary profile of catecholamines and metabolites in Parkinson patients with deep brain stimulation

• Type: Article in International Scientific Journal
• Date: 2014

Authors

guimaraes, j (Author) FMUP; vieira-coelho, ma (Author) FMUP; moura, e (Author) Other; afonso, j (Author) Other; rosas, mj (Author) Other; vaz, r (Author) Other; garrett, c (Author) FMUP

Journal

Title: European Journal of Neurology

Vol. 21

Pages: 353-356

ISSN: 1351-5101

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-008-WB6

DOI: 10.1111/ene.12161

Abstract (EN): Background and purposeDeep brain stimulation of the subthalamic nucleus (DBS-STN) is thought to continuously alter the activity of STN neurons in Parkinson's disease (PD). A chronic decrease in the levodopa dose with continuous STN stimulation may induce plastic neuronal changes. ObjectiveThe objective of this work was to study urinary excretion of catecholamines in patients with PD before and after DBS-STN. MethodsTwenty-three patients were submitted to DBS-STN, and evaluated before and after surgery with respect to catecholamines and metabolites in 24-h urine measured by high-performance liquid chromatography with electrochemical detection. ResultsOf the 23 patients evaluated, a significant decrease of about 60% in the urinary excretion of l-3,4-dihydroxyphenylalanine (l-DOPA; in nmol/mg creatinine/24h) was observed 1week after DBS-STN. Moreover, in 17 patients with a follow-up of 8 weeks after surgery, there was a further 50% decrease in urinary l-DOPA levels, dropping to about 75% of the values before surgery. There was also a significant decrease in dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) levels 1week after DBS-STN that was no longer present 8weeks after. A significant increase in the DA/l-DOPA ratio was observed 1week after surgery, with a further increase 8weeks after surgery. ConclusionAfter DBS-STN, the DA/l-DOPA ratio, an indirect measure of DA synthesis, increased. These results show that DBS-STN may improve the efficacy of oral levodopa.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4