Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases-A mechanistic approach

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Maria Teresa Baltazar (Author) Other; Ricardo Jorge Dinis Oliveira (Author) FMUP; Mariade Lourdes Bastos (Author) FFUP; Aristidis M Tsatsakis (Author) Other; Jose Alberto Duarte (Author) FADEUP; Felix Carvalho (Author) FFUP

Journal

Title: Toxicology Letters

Vol. 230

Pages: 85-103

ISSN: 0378-4274

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 207 Citations

Scopus - 231 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-009-TMZ

DOI: 10.1016/j.toxlet.2014.01.039

Abstract (EN): The etiology of most neurodegenerative disorders is multifactorial and consists of an interaction between environmental factors and genetic predisposition. The role of pesticide exposure in neurodegenerative disease has long been suspected, but the specific causative agents and the mechanisms underlying are not fully understood. For the main neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis there are evidences linking their etiology with long-term/low-dose exposure to pesticides such as paraquat, maneb, dieldrin, pyrethroids and organophosphates. Most of these pesticides share common features, namely the ability to induce oxidative stress, mitochondrial dysfunction, alpha-synuclein fibrillization and neuronal cell loss. This review aims to clarify the role of pesticides as environmental risk factors in genesis of idiopathic PD and other neurological syndromes. For this purpose, the most relevant epidemiological and experimental data is highlighted in order to discuss the molecular mechanisms involved in neurodegeneration.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19