A liver schwannoma observed in a female Sprague-Dawley rat treated with MNU

• Type: Article in International Scientific Journal
• Date: 2014

Authors

C. I. Teixeira- Guedes (Author) Other; A. I. Faustino-Rocha (Author) Other; D. Talhada (Author) Other; José Alberto Ramos Duarte (Author) FADEUP; R. Ferreira (Author) Other; F. Seixas (Author) Other; P. A. Oliveira (Author) Other

Journal

Title: Experimental and Toxicologic Pathology

Vol. 66

Pages: 125-128

ISSN: 0940-2993

Publisher: Urban und Fischer Verlag Jena

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Scientific classification

FOS: Social sciences

Other information

Authenticus ID: P-008-QD0

DOI: 10.1016/j.etp.2013.11.003

Abstract (EN): Background: Schwannoma is a tumor of the nervous system composed by Schwann cells. It can occur naturally in several tissues of the body in both humans and animals. Diaphragmatic hernia can be congenital or acquired and is defined as a protrusion of abdominal viscera into the thoracic cavity. Materials and methods: The animal was a female rat from an experiment of mammary tumor chemically induced. It was injected with N-methyl. N-nitrosourea (MNU) and died spontaneously at 22 weeks of age. Results: The animal had a diaphragmatic hernia and a hemorrhagic and multicystic mass in the liver herniated lobule. Microscopically the liver displayed a well circumscribed mass that was a tumor with hemorrhagic areas, necrosis and Antoni A and Antoni B patterns. It also displayed occasional positivity to vimentin and diffuse positivity to S-100 and NSE. Conclusion: The tumor was a schwannoma with the origin in the Glisson's capsule. © 2013 Elsevier GmbH.

Language: English

Type (Professor's evaluation): Scientific