NIFEDIPINE DIMINISHES EXERCISE-INDUCED MUSCLE DAMAGE IN MOUSE

• Type: Article in International Scientific Journal
• Date: 1992

Authors

duarte, jar (Author) FADEUP; soares, jmc (Author) Other; appell, hj (Author) Other

Journal

Title: International Journal of Sports Medicine

Vol. 13

Pages: 274-277

ISSN: 0172-4622

Publisher: Thieme

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 11 Citations

Scientific classification

FOS: Medical and Health sciences > Health sciences

Other information

Authenticus ID: P-001-PPY

DOI: 10.1055/s-2007-1021266

Abstract (EN): The purpose of this study was to evaluate the effects of a calcium channel blocker (nifedipine) on the severity of muscle damage induced by intensive exercise. Male Charles River mice were assigned to four groups (8 mice/group): normal control (C), nifedipine (N), nifedipine and exercise (N + E) and exercise (E). The animals of the C group were not submitted to any exercise nor to drug administration. The animals of the N group received 1 mg.kg-1 per day of nifedipine (Adalat(R) 10 mg, Bayer AG), per os, during 3 days. The mice of the N + E group were submitted to a treadmill run (0-degrees-slope) at 1000 m.h-1 (80% of their maximal speed) for 1 hour. In this group, the administration of the drug was under the same conditions as for the N group. The administration started 24 h before the run. The E group was submitted to the same exercise protocol as the animals of N + E group. The soleus muscle was excised for light and electron microscopic evaluation using routine histological techniques. In the C and N groups no morphological alterations were detected. In the E group the number of alterations of striated pattern was twice that in the N + E group. The number of fibres with central nuclei was 35% in the E group but only 8 % in the N + E group. The total number of damaged fibres was significantly higher in the E group. The results suggest that nifedipine may give protection to exercise-induced skeletal muscle damage in mouse, probably because the blocking of channels impaired Ca2+ influx; and the results of this study therefore confirm earlier contentions about the possible role of calcium ions in producing muscle damage after work.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4