SKELETAL-MUSCLE DAMAGE DURING TOURNIQUET-INDUCED ISCHEMIA - THE INITIAL STEP TOWARDS ATROPHY AFTER ORTHOPEDIC-SURGERY

• Type: Article in International Scientific Journal
• Date: 1993

Authors

appell, hj (Author) Other; gloser, s (Author) Other; duarte, jar (Author) FADEUP; zellner, a (Author) Other; soares, jmc (Author) Other

Journal

Title: European Journal of Applied Physiology and Occupational Physiology

Vol. 67

Pages: 342-347

ISSN: 0301-5548

Publisher: Springer

Indexing

ISI Web of Knowledge - 47 Citations

Scopus - 52 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-001-MK9

DOI: 10.1007/bf00357633

Abstract (EN): Muscle biopsies from the vastus lateralis muscle of patients who had undergone anterior cruciate ligament surgery under conditions of tourniquet-induced ischaemia were examined under the electron microscope at different periods of time up to 90 min of ischaemia. The severity of the alterations in ultrastructure appeared to depend on the period of ischaemia. The pathological changes consisted of accumulation of lysosomes, persistent intrafibre oedema, and some extracellular oedema. Signs of fibre necrosis were found after 90 min of ischaemia. Capillary ultrastructure was only altered with regard to some swelling of the endothelium and marked thickening of the basement membrane. It was concluded that skeletal muscle could be severely affected even during relatively short periods of ischaemia, which might facilitate the development of muscle atrophy during immobilization after orthopaedic surgery.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6