Administration of tourniquet

• Type: Article in International Scientific Journal
• Date: 1996

Authors

Duarte, JA (Author) FADEUP; Gloser, S (Author) Other; Remiao, F (Author) FFUP; Carvalho, F (Author) FFUP; Bastos, ML (Author) FFUP; Soares, JMC (Author) Other; Appell, HJ (Author) Other

Journal

Title: Archives of Orthopaedic and Trauma Surgery

Vol. 116

Pages: 97-100

ISSN: 0936-8051

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 13 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-00J-9GD

DOI: 10.1007/s004020050077

Abstract (EN): One hindlimb of mice was subjected to 60, 90 and 120 min ischemia by application of a tourniquet followed by a 60-min reperfusion period. An additional experimental group received a tourniquet for 90 min without subsequent reperfusion. The soleus muscle (from the contralateral side also as control) was removed and evaluated for muscle weight, protein weight, protein content, and glutathione concentrations. Ischemia alone without subsequent reperfusion did not produce significant changes. With postischemic reperfusion, the protein content and muscle weight increased, probably because of an increased capillary permeability, leading to muscle edema. Oxidative stress was also present during reperfusion, correlating well with the changes in protein content. The intensity of these alterations appeared to depend on the period of ischemia.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4