Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Cesar Augusto Alvarenga (Author) Other; Jose Manuel Lopes (Author) FMUP; Joao Vinagre (Author) Other; Paula Itagyba Paravidino (Author) Other; Marcelo Alvarenga (Author) Other; Adilson Prando (Author) Other; Lisias Nogueira Castilho (Author) Other; Paula Soares (Author) FMUP; Athanase Billis (Author) Other

Journal

Title: Sao Paulo Medical Journal

Vol. 130

Pages: 57-60

ISSN: 1516-3180

Publisher: Associação Paulista de Medicina

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 8 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-002-H2S

DOI: 10.1590/s1516-31802012000100010

Abstract (EN): CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4