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Insights into melanoma: targeting the mTOR pathway for therapeutics

Title
Insights into melanoma: targeting the mTOR pathway for therapeutics
Type
Another Publication in an International Scientific Journal
Year
2012
Authors
Helena Populo
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. View Authenticus page Without ORCID
Jose Manuel Lopes
(Author)
FMUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Journal
Vol. 16
Pages: 689-705
ISSN: 1472-8222
Publisher: Taylor & Francis
Scientific classification
FOS: Medical and Health sciences > Basic medicine
Other information
Authenticus ID: P-002-8N7
Abstract (EN): Introduction: Cutaneous melanoma represents <5% of all skin cancers, but is responsible for the majority of skin cancer-related deaths. Ocular melanoma is the most common primary eye tumor in adults, and accounts for approximately 5% of all melanomas. Despite new diagnostic and therapeutic tools, the overall survival of patients treated for melanoma has not improved and most patients die of metastatic disease. Therefore, clarification of the molecular mechanisms underlying the etiopathogenesis of cutaneous and ocular melanomas may help determining the prognosis and tailoring therapy of patients harboring melanomas. Areas covered: In this review the authors aim to survey relevant research in the molecular mechanisms underlying melanomagenesis, and therapies under evaluation with emphasis in the mTOR pathway. Expert opinion: Despite an increasingly understanding of the genetics and biochemistry of melanoma, the mechanisms underlying their complex interactions are still poorly understood. Their clarification will lead to more successful therapeutic strategies and evidence-based management of patients with melanoma. More active drug combinations together with appropriate melanoma patient stratification based on molecular biomarkers will be essential for new advances in melanoma therapy.
Language: English
Type (Professor's evaluation): Scientific
Contact: psoares@ipatimup.pt
No. of pages: 17
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