THYROID NODULAR HYPERPLASIA - CHROMOSOMAL STUDIES IN 14 CASES

• Type: Article in International Scientific Journal
• Date: 1993

Authors

ROQUE, L (Author) Other; GOMES, P (Author) Other; CORREIA, C (Author) Other; SOARES, P (Author) Other; SOARES, J (Author) Other; CASTEDO, S (Author) FMUP

Journal

Title: Cancer Genetics and Cytogenetics

Vol. 69

Pages: 31-34

ISSN: 0165-4608

Publisher: Elsevier B.V.

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 24 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-001-MSS

DOI: 10.1016/0165-4608(93)90108-x

Abstract (EN): Cytogenetic study of 14 thyroid nodular hyperplasias revealed a hyperdiploid karyotype in two cases (14%) and a normal chromosomal complement in the remaining cases. Some of the numerical alterations found were identical to the ones considered characteristic of a subset of thyroid adenomas (+5, +7, +9, +12, +14, and +16). Our findings suggest that the cytogenetic events involved in the pathogenesis of thyroid hyperplastic lesions and benign tumors may be closely related, which supports the hypothesis of a biologic ''continuum'' between these two types of lesions.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4