Poorly differentiated carcinomas of the thyroid gland - A review of the clinicopathologic features of a series of 28 cases of a heterogeneous, clinically aggressive group of thyroid tumors

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Sobrinho Simoes, M (Author) FMUP; Sambade, C (Author) Other; Fonseca, E (Author) Other; Soares, P (Author) FMUP

Journal

Title: International Journal of Surgical Pathology

Vol. 10

Pages: 123-131

ISSN: 1066-8969

Publisher: SAGE

Indexing

ISI Web of Knowledge - 50 Citations

Scopus - 62 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-PTY

DOI: 10.1177/106689690201000205

Abstract (EN): We evaluated the clinicopathologic, immunohistochemical, lectin histochemical, ultrastructural and morphometric characteristics of a series of 28 poorly differentiated carcinomas of the thyroid (PDCT). The 28 tumors were classified according to their predominant growth pattern as insular (n=12), trabecular (n=10) and solid subtypes (n=6). The overall mortality rate was 46%. No significant differences were found among the 3 subtypes. Data obtained by lectin histochemistry, electron microscopy, and morphometry point to a closer relationship of PDCT to follicular than to papillary carcinoma. Our results do not support the subdivision of PDCT into subtypes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9