Absence of the BRAF and the GRIM-19 Mutations in Oncocytic (Hurthle Cell) Solid Cell Nests of the Thyroid

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Jose Cameselle Teijeiro (Author) Other; Rute Ferreira (Author) Other; Nuria Carames (Author) Other; Ihab Abdulkader (Author) Other; Valdemar Maximo (Author) FMUP; Paula Soares (Author) FMUP; Manuel Sobrinho Simoes (Author) FMUP

Journal

Title: American Journal of Clinical Pathology

Vol. 137

Pages: 612-618

ISSN: 0002-9173

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 15 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-002-BS5

DOI: 10.1309/ajcpb0rxypacll5k

Abstract (EN): We report the first case of oncocytic solid cell nests (SCNs), found in the right lobe of the thyroid of a 70-year-old man. Conventional SCNs and 1 papillary microcarcinoma (mPTC) were also found in the left lobe. In the oncocytic SCNs, 80% of the main cells showed oncocytic cytoplasm immunoreactive for porin and proteins of the SDHB and SDHA genes. Positivity for cytokeratin 19, p63, galectin-3, and HBME-1 and negativity for thyroglobulin, thyroperoxidase, vimentin, Oct-4, and alpha-fetoprotein were found in oncocytic and conventional SCNs. An inverse correlation was found between oncocytic metaplasia and p63. Association with C cells was confirmed at protein and messenger RNA levels in both types of SCNs. No germinal mutation of GRIM-19 was detected. No somatic BRA F mutation was found in any of the SCNs nor in the mPTC. We conclude that SCNs may acquire mitochondrial alterations similar to those seen in follicular and C cells, as well as in their respective tumors.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7