Online Individualized Dose Estimation

• Type: Article in International Conference Proceedings Book
• Date: 2009

Authors

Conceicao Rocha (Author) Other; Teresa Mendonca (Author) FCUP; Eduarda E Silva (Author) FCUP

Conference proceedings International

Title: WISP 2009: 6TH IEEE INTERNATIONAL SYMPOSIUM ON INTELLIGENT SIGNAL PROCESSING, PROCEEDINGS

Pages: 275-279

6th IEEE International Symposium on Intelligent Signal Processing

Budapest, HUNGARY, AUG 26-28, 2009

Indexing

ISI Web of Knowledge - 0 Citations

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Scientific classification

FOS: Engineering and technology > Electrical engineering, Electronic engineering, Information engineering

Other information

Authenticus ID: P-003-SDF

DOI: 10.1109/wisp.2009.5286553

Abstract (EN): The development of automated individualized drug dosage regimens, namely in general anaesthesia environment, has been a subject of interest in the last decades. The use of continuous intravenous drug administration aims at, accurately, maintaining the system at a desired target effect concentration level. Different methods have been proposed for the design of individualized dosage regimens. In this study individual drug dose design is achieved through the characterization of transient initial response induced by a bolus administration of drug. This approach is based on the statistical analysis of the data using Walsh-Fourier spectral analysis which provides information about patient dynamics, allowing the on-line drug dose design using multiple linear least squares and quantile regression technics. The proposed methodology is illustrated in the case where the effect measured on the patient corresponds to the neuromuscular blockade (NMB) level and the drug to the muscle relaxant atracurium.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5