Pharmaceutical trace analysis in aqueous environmental matrices by liquid chromatography-ion trap tandem mass spectrometry

• Type: Article in International Scientific Journal
• Date: 2009

Authors

madureira, tv (Author) Other; barreiro, jc (Author) Other; rocha, mj (Author) ICBAS; cass, qb (Author) Other; M E Tiritan (Author) FFUP

Journal

Title: Journal of Chromatography A

Vol. 1216 No. 48

Pages: 7033-7042

ISSN: 0021-9673

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 46 Citations

Scopus - 47 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-003-F0Y

DOI: 10.1016/j.chroma.2009.08.060

Abstract (EN): An analytical method based on solid-phase extraction followed by liquid chromatography tandem mass spectrometry with an ion trap analyser was developed and validated for the quantification of a series of pharmaceutical compounds with distinct physical-chemical characteristics in estuarine water samples. Method detection limits were between 0.03 and 16.4 ng/L The sensitivity and the accuracy obtained associated with the inherent confirmatory potential of ion trap tandem mass spectrometry (IT-MS/MS) validates its Success as an environmental analysis tool. Two MS/MS transitions were used to confirm compound identity. Almost all pharmaceuticals were detected at ng/L level in at least one sampling site of the Douro River estuary, Portugal.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10