High levels of C-reactive protein are associated with reduced vagal modulation and low physical activity in young adults

• Type: Article in International Scientific Journal
• Date: 2012

Authors

soares-miranda, l (Author) Other; negrao, ce (Author) Other; antunes-correa, lm (Author) Other; nobre, ts (Author) Other; silva, p (Author) Other; santos, r (Author) Other; vale, s (Author) Other; mota, j (Author) FADEUP

Journal

Title: Scandinavian Journal of Medicine and Science in Sports

Vol. 22

Pages: 278-284

ISSN: 0905-7188

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 5 Citations

Scientific classification

FOS: Medical and Health sciences > Health sciences

Other information

Authenticus ID: P-002-BNT

DOI: 10.1111/j.1600-0838.2010.01163.x

Abstract (EN): The purpose of this study was to examine the relationship between cardiac autonomic control derived from heart rate variability (HRV), high-sensitivity C-reactive protein (hs-CRP) and physical activity (PA) levels measured using accelerometers. A total of 80 healthy university students volunteered to participate in this study (20.56 +/- 0.82 years, 1.36 +/- 1.5 mg/L of hs-CRP). The participants were divided into groups based on tertiles of hs-CRP. Analysis of covariance adjusted to PA was used to assess group differences in HRV. Associations between hs-CRP, HRV indices and PA were analyzed using Pearson's correlation. The participants at the highest tertile of hs-CRP (tertile 3) had lower cardiac vagal modulation (SDNN, tertile 1=78.05 +/- 5.9,tertile 2=82.43 +/- 5.9,tertile 3=56.03 +/- 6.1; SD1, tertile 1=61.27 +/- 5.3, tertile 2=62.93 +/- 5.4, tertile 3=40.03 +/- 5.5). In addition, vagal indices were inversely correlated with hs-CRP but positively correlated with PA (SDNN r=-0.320, SD1 r=-0.377; SDNN r=0.304, SD1 r=0.299; P<0.05). Furthermore, the most physically active subjects had lower levels of hs-CRP and the highest levels of vagal modulation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7