Exercise and cardiac oxidative stress [Exercício e stress oxidativo cardíaco]

• Type: Article in International Scientific Journal
• Date: 2003

Authors

A. Ascensão (Author) FADEUP; J. Magalhães (Author) FADEUP; J. Soares (Author) FADEUP; J. Oliveira (Author) FADEUP; J. A. Duarte (Author) FADEUP

Journal

Title: Boletim da Sociedade Portuguesa de Cardiologia

Vol. 22

Pages: 651-678

ISSN: 0304-4750

Publisher: Sociedade Portuguesa De Cardiologia

Indexing

ISI Web of Knowledge

Scopus - 23 Citations

Other information

Authenticus ID: P-007-B7C

Abstract (EN): Cardiac muscle is frequently affected by many stimuli responsible for loss of cell homeostasis, including physical exercise. While exercise has been presented as a recommended activity for health reasons, it also provides favorable conditions for additional production of reactive oxygen species. These compounds are associated with fundamental mechanisms of cell metabolism but are also related to the etiology and pathophysiology of some cardiac diseases. Cardiac muscle tissue has a high oxidative metabolic rate and relatively low activity of the main antioxidant enzymes, which could enhance its susceptibilitiy-to-oxidative injury after acute exercise. However, physical training could be considered an important stimulus for the different antioxidant systems like glutathione and those related to the activity of some important antioxidant enzymes in myocardial protection such as superoxide dismutase and glutathione peroxidase. Endurance training seems to induce upregulation in some antioxidant defenses, protecting cardiac muscle in potentially harmful situations that induce additional oxidative stress. Nevertheless, the mechanisms related to this cross-tolerance effect of training are not yet well understood.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 28