Crystalline inclusions in hepatocytes and associated interhepatocytic macrophages from female Ohrid trout (Salmo letnica Kar.)

• Type: Article in International Scientific Journal
• Date: 2009

Authors

jordanova, m (Author) Other; miteva, n (Author) Other; santos, n (Author) Other; malhao, f (Author) Other; rocha, e (Author) ICBAS

Journal

Title: TISSUE & CELL

Vol. 41

Pages: 281-285

ISSN: 0040-8166

Publisher: CHURCHILL LIVINGSTONE

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 5 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-HBY

DOI: 10.1016/j.tice.2008.12.005

Abstract (EN): When characterizing the liver ultrastructure in Ohrid trout, we noticed that cells often displayed unusual cytoplasmic crystalline inclusions. Their morphology varied much, concerning the size, shape and electron density, showing aspects never reported in fish liver. in hepatocytes, the inclusions existed in close topographical relationship with dense bodies (often within them). Such "crystals" inclusions also existed in macrophages and in biliary passages lumina. Data revealed seasonal/breeding-related changes of the dense bodies and crystalline inclusions within hepatocytes; decreasing from the earliest to the more advanced ovary maturation stages. Additionally, based on the negative correlations between the amounts of dense bodies and of "crystals" and the ovary somatic ratio, we suggested there might be connections between the sex steroids status and the inclusions formation. A positive correlation between the quantities of "crystals" and of dense bodies further suggested that the inclusions might derive from normal processes, e.g., the females' cyclic liver changes, that involves dense bodies' turnover. However, a toxicological aetiology cannot be excluded. Additionally, multiple mechanisms can contribute to the "crystals" genesis. Facing literature reports and because the inclusions content seemed washed out during tissue processing, they are likely lipid in nature, but their exact composition and genesis require further analyses.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5