Dogs mean arterial pressure and heart rate responses during high propofol plasma concentrations estimated by a pharmacokinetic model

• Type: Article in International Scientific Journal
• Date: 2011

Authors

silva, a (Author) Other; ribeiro, lm (Author) Other; bressan, n (Author) Other; oliveira, p (Author) FMUP; ferreira, da (Author) Other; antunes, lm (Author) Other

Journal

Title: Research in Veterinary Science

Vol. 91

Pages: 278-280

ISSN: 0034-5288

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Scientific classification

FOS: Agrarian Sciences > Veterinary science

Other information

Authenticus ID: P-002-M5V

DOI: 10.1016/j.rvsc.2011.01.001

Abstract (EN): Propofol total intravenous anesthesia should provide stability of the cardiovascular system. In this study, mean arterial pressure and heart rate were evaluated in eight healthy dogs anesthetized with increasing rates of propofol. The cerebral state index (CSI) was studied as an additional parameter. Although the estimated propofol plasma concentration reached a maximal value of 15.3 mu g ml(-1), no hypotension or bradycardia were observed. Exploration of each animal's data revealed high inter-individual variability regarding mean arterial pressure and heart rate. Considering the logarithmic of the concentration, a moderate depressant effect of propofol on mean arterial pressure was revealed in five dogs but the effect was not followed on heart rate.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3