Immunological alterations induced by polyamine derivatives on murine splenocytes and human mononuclear cells

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Cordeiro Da Silva, A (Author) FFUP; Tavares, J (Author) FFUP; Araujo, N (Author) Other; Cerqueira, F (Author) Other; Tomas, A (Author) ICBAS; Lin, PKT (Author) Other; Ouaissi, A (Author) Other

Journal

Title: International Immunopharmacology

Vol. 4

Pages: 547-556

ISSN: 1567-5769

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 19 Citations

Scopus - 20 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-AZG

DOI: 10.1016/j.intimp.2004.02.009

Abstract (EN): Three polyamine derivatives assigned as bis-naphthalimidopropyl putrescine (BNIPPut), spermidine (BNIPSpd) and spermine (BNISpm) were studied to determine their effects oil the proliferation of murine splenocytes and human peripheral blood mononuclear cells (PBMC) induced by the mitogens, Con A, LPS and PHA. All Compounds showed a dose dependent inhibitory effect on mouse and human T cell proliferation induced by the mitogens, with BNIPPut exhibiting the most potent antiproliferative activity, followed by BNIPSpd and by BNIPSpm, respectively (Put>Spd>Sm), when considering human T cells. This suppressive activity also affects the capacity of mouse spleen cells to produce Th1 cytokines, namely IL-2 and INF-gamma after in vitro stimulation with Con A. The polyamine-induced inhibition also Occurred in the case of LPS-stimulated B cells with a marked decrease of CD69 expression by these cells. Furthermore, the ability for these polyamine derivatives to induce apoptosis on Con A-stimulated splenocytes could be related to their antiproliferative activity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10