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FISH MAJOR HISTOCOMPATIBILITY COMPLEX GENES - AN EXPANSION

Title
FISH MAJOR HISTOCOMPATIBILITY COMPLEX GENES - AN EXPANSION
Type
Article in International Scientific Journal
Year
1995
Authors
DIXON, B
(Author)
Other
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VANERP, SHM
(Author)
Other
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RODRIGUES, PNS
(Author)
ICBAS
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EGBERTS, E
(Author)
Other
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STET, RJM
(Author)
Other
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Journal
Vol. 19
ISSN: 0145-305X
Publisher: Elsevier
Scientific classification
FOS: Medical and Health sciences > Basic medicine
CORDIS: Health sciences
Other information
Authenticus ID: P-008-QB3
Abstract (EN): The advent of polymerase chain reaction technology has provoked a large amount of progress in the field of fish major histocompatibility complex (MHC) research. Many new teleost sequences have been reported in the last four years, including representatives of all classes of MHC genes. While the intronexon structure of teleost MHC genes is now becoming clear, the organisation of the genes within the teleost MHC is still unclear. The sequences reported to date have been used for phylogenetic analysis and, due to their evolutionary position, are discussed in relation to hypotheses regarding the origin of the MHC. Teleost MHC gene sequences are also examined to see if conserved features of both the nucleotide and amino acid sequences of higher vertebrate MHC genes are present. Differences in these features will reflect functional differences between teleost and mammalian MHC genes and may also have evolutionary implications.
Language: English
Type (Professor's evaluation): Scientific
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