Modulation of hepatic redox status and mitochondrial metabolism by exercise: Therapeutic strategy for liver diseases

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Antonio Ascensao (Author) FADEUP; Maria J Martins (Author) FMUP; Estela Santos Alves (Author) Other; Ines O Goncalves (Author) Other; Piero Portincasa (Author) Other; Paulo J Oliveira (Author) Other; Jose Magalhaes (Author) FADEUP

Journal

Title: Mitochondrion

Vol. 13

Pages: 862-870

ISSN: 1567-7249

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 24 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-006-JQX

DOI: 10.1016/j.mito.2013.07.002

Abstract (EN): Liver steatosis (non-alcoholic fatty liver disease, NAFLD) is deemed as the hepatic face of the metabolic syndrome, with both physical inactivity and hypercaloric/unbalanced diet, together with increasing age playing a role as predisposing factors. Consequently, one of the most effective strategies used to counteract this scenario is physical exercise. Given the importance of redox signaling in cellular remodeling, in which mitochondria are closely implicated along with important roles on substrate oxidation, here we briefly review the effects of both acute and chronic forms of physical exercise on the modulation of hepatic redox state, highlighting the relevance of mitochondrial metabolism and function in the induction of liver phenotypes that antagonize metabolic alterations associated with liver metabolic diseases.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9