INDUCTION AND EXPRESSION OF PROTECTIVE T-CELLS DURING MYCOBACTERIUM-AVIUM INFECTIONS IN MICE

• Type: Article in International Scientific Journal
• Date: 1992

Authors

APPELBERG, R (Author) ICBAS; PEDROSA, J (Author) Other

Journal

Title: Clinical and Experimental Immunology

Vol. 87

Pages: 379-385

ISSN: 0009-9104

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 12 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-001-PS9

Abstract (EN): Mycobacterium avium is an opportunistic pathogen that infects individuals suffering from chronic lung disease or immunocompromised patients such as AIDS patients. Here we show that a highly virulent isolate of M. avium proliferated as extensively in T cell deficient as in immunocompetent mice. T cell deficient mice allowed a progressive growth of a less virulent AIDS-derived isolate of M. avium while immunocompetent mice arrested the growth of this isolate. Adoptive transfer of T cell enriched spleen cells between congenic strains of mice differing at the Bcg/Ity/Lsh locus showed that only naturally resistant BALB/c.Bcg(r) (C.D2) mice infected with the highly virulent strain of M. avium or the naturally susceptible BALB/c mice infected with the lower virulence isolate developed protective T cells and that these cells only mediated protection when transferred to naturally susceptible. but not to naturally resistant. mice. Both strains of M. avium proliferated in bone marrow-derived macrophages cultured in vitro and they were both susceptible to the bacteriostatic effects induced in the macrophages by crude lymphokines produced by concanavalin A-stimulated spleen cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7