Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Gomes, MS (Author) ICBAS; Florido, M (Author) Other; Cordeiro, JV (Author) Other; Teixeira, CM (Author) Other; Takeuchi, O (Author) Other; Akira, S (Author) Other; Appelberg, R (Author) ICBAS

Journal

Title: Immunology

Vol. 111

Pages: 179-185

ISSN: 0019-2805

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 20 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-BRC

DOI: 10.1111/j.1365-2567.2003.01807.x

Abstract (EN): The role of the Toll-like receptor (TLR)-2 in the generation of protective immunity to Mycobacterium avium was evaluated using gene-disrupted mice. TLR-2(-/-) mice were more susceptible than wild-type C57Bl/6 mice to M. avium strains that were able to proliferate in vivo before the development of protective immunity and mycobacteriostasis. In contrast, the elimination of non-virulent strains was not affected by the mutation. The generation of interferon-gamma (IFN-gamma)-producing T cells and the expression of the interleukin-12 p40 gene were reduced in TLR-2-deficient mice as compared to C57Bl/6 mice early during infection with M. avium strain 2447. The generation of protective CD4(+) T cells was also compromised in the mutated mice as compared with the controls. Our data show that TLR-2 is required for optimal immunity against certain virulent M. avium strains.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7