Liver transplantation for the treatment of type I familial amyloidotic polyneuropathy [Trasplante hepático para el tratamiento de la polineuropatía amiloidótica familiar tipo I.]

• Type: Article in International Scientific Journal
• Date: 1993

Authors

Lopez Andreu, FR (Author) Other; Munar Ques, M (Author) Other; Parrilla, P (Author) Other; Escribano Soriano, JB (Author) Other; Costa, PP (Author) Other; Costa, PM (Author) ICBAS; Almeida, MR (Author) ICBAS; Pons, JA (Author) Other; Robles, R (Author) Other; Sanchez Bueno, F (Author) Other

Journal

Title: Medicina Clinica

Vol. 101

Pages: 581-583

ISSN: 0025-7753

Publisher: Elsevier

Indexing

ISI Web of Knowledge

Scopus - 8 Citations

Other information

Authenticus ID: P-007-AXV

Abstract (EN): The first liver transplantation carried out in Spain for the treatment of type I familial amyloidotic polyneuropathy (FAP I) is presented. The reason for the operation was based on the liver being responsible for the synthesis of abnormal transtirretin (TTR) constituting the peculiar amyloid of the disease. Following transplantation a rapid and noticeable decrease in abnormal TTR was observed and the evolution of the clinical picture after 18 months of surgery is favorable with progressive improvement of the neurologic symptoms and normal function of the graft. These encouraging results coincide with those of the Swedish group of Umea, the pioneer of this procedure.

Language: Spanish

Type (Professor's evaluation): Scientific

No. of pages: 3