Topical cyclosporine for severe dry eye disease in liver-transplanted Portuguese patients with familial amyloidotic polyneuropathy (ATTRV30M)

• Type: Article in International Scientific Journal
• Date: 2013

Authors

beirao, jm (Author) Other; matos, me (Author) Other; beirao, ib (Author) ICBAS; costa, pp (Author) ICBAS; torres, pa (Author) Other

Journal

Title: European Journal of Ophthalmology

Vol. 23

Pages: 156-163

ISSN: 1120-6721

Publisher: WICHTIG PUBLISHING

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-006-DCY

DOI: 10.5301/ejo.5000197

Abstract (EN): PURPOSE. Evaluation of the use of topical cyclosporine eyedrops in the treatment of severe dry eye disease in liver transplanted patients with familial amyloidotic polyneuropathy (FAP) unresponsive to therapy with artificial tears and lacrimal plugs. METHODS. A prospective clinical study of 5 patients (10 eyes) admitted to the Ophthalmology Department of the Centro Hospitalar do Porto with severe dry eye disease refractory to artificial tears and lacrimal plug treatments. Evaluation of the patients included best-corrected visual acuity, corneal punctuate fluorescein staining, tear break-up time, Schirmer test without anesthesia, and Ocular Surface Disease Index. Patients were observed at time 0, and at 3, 7, and 11 months. RESULTS. Treatment with topical cyclosporine improved all studied parameters from baseline, and in all the patients (p<0.001). The safety profile was excellent, without topical or systemic adverse events. CONCLUSIONS. Topical cyclosporine was beneficial in the treatment of severe dry eye disease in liver transplanted patients with FAP.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8