IMMUNOASSAY FOR TRANSTHYRETIN VARIANTS ASSOCIATED WITH AMYLOID NEUROPATHY

• Type: Article in International Scientific Journal
• Date: 1993

Authors

costa, pmp (Author) ICBAS; teixeira, a (Author) Other; saraiva, mjm (Author) ICBAS; costa, pp (Author) Other

Journal

Title: Scandinavian Journal of Immunology

Vol. 38

Pages: 177-182

ISSN: 0300-9475

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 12 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-001-MVF

DOI: 10.1111/j.1365-3083.1993.tb01710.x

Abstract (EN): An anti-transthyretin (TTR) mouse monoclonal antibody (88.6.FD6) of IgG1 subclass, obtained using as immunogen TTR from the serum of a patient with familial amyloidotic polyneuropathy, was found to bind to sera from carriers of several amyloidogenic TTR variants associated with peripheral neuropathy, but not to normal sera or sera from carriers of non-pathogenic or cardiomyopathic variants, in an ELISA performed under special conditions. Further characterization suggests that it recognizes an epitope near the N-terminal side of the TTR monomer. We propose that this epitope is exposed in amyloid and could be implicated in fibril deposition in the peripheral nervous system.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6