Angiogenesis and chronic inflammation: Cause or consequence?

• Type: Another Publication in an International Scientific Journal
• Date: 2007

Authors

costa, c (Author) Other; incio, j (Author) Other; soares, r (Author) FMUP

Journal

Title: Angiogenesis

Vol. 10

Pages: 149-166

ISSN: 0969-6970

Publisher: Springer Nature

Indexing

ISI Web of Knowledge

Scopus - 330 Citations

Other information

Authenticus ID: P-007-JBA

DOI: 10.1007/s10456-007-9074-0

Abstract (EN): Evidence has been gathered regarding the association between angiogenesis and inflammation in pathological situations. These two phenomena have long been coupled together in many chronic inflammatory disorders with distinct etiopathogenic origin, including psoriasis, rheumatoid arthritis, Crohn's disease, diabetes, and cancer. Lately, this concept has further been substantiated by the finding that several previously established non-inflammatory disorders, such as osteoarthritis and obesity, display both inflammation and angiogenesis in an exacerbated manner. In addition, the interplay between inflammatory cells, endothelial cells and fibroblasts in chronic inflammation sites, together with the fact that inflammation and angiogenesis can actually be triggered by the same molecular events, further strengthen this association. Therefore, elucidating the underlying cellular and molecular mechanisms that gather together the two processes is mandatory in order to understand their synergistic effect, and to develop new therapeutic approaches for the management of these disorders that cause a great deal of discomfort, disability, and in some cases death. © 2007 Springer Science + Business Media B.V.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18