Dissolution characteristics of divisible tablets

• Type: Article in International Scientific Journal
• Date: 2000

Authors

costa, p (Author) FFUP; amaral, h (Author) Other; lobo, jms (Author) Other

Journal

Title: S.T.P. Pharma Sciences

Vol. 10

Pages: 373-377

ISSN: 1157-1489

Publisher: Editions de Sante

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-000-Z6F

Abstract (EN): The objective of this work was to study the in vitro dissolution equivalence and divisibility of three brands of captopril tablets, applying the tablet divisibility assay described in the Portuguese Pharmacopoeia VI (FP VI). At the same time, the physical characteristics (hardness, friability) and release characteristics of whole tablets and halves and quarters resulting from the division of tablets, were analysed The dissolution test was carried out using a USP paddle apparatus. Captopril tablets (25 mg) with crossed scoring were tested. In this way, captopril doses of 25 mg (one tablet), 12.5 mg (one half tablet) and 6.25 mg (one quarter tablet) can be administered. The results obtained with tablet halves, and particularly tablet quarters, exhibited broad variations in weight which could give rise to significant differences in plasma levels.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5