Evaluation of an in vitro dissolution and permeation apparatus for oral solid pharmaceutical dosage forms

• Type: Article in International Scientific Journal
• Date: 1997

Authors

Ferreira, DC (Author) FFUP; Costa, P (Author) FFUP; Morgado, R (Author) Other; Lobo, JMS (Author) Other

Journal

Title: Drug Development and Industrial Pharmacy

Vol. 23

Pages: 387-392

ISSN: 0363-9045

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 1 Citation

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-001-CBC

DOI: 10.3109/03639049709146141

Abstract (EN): An apparatus based in the USP dissolution test, the F-C-SL apparatus (Ferreira-Costa-Sousa Lobo), was developed that allowed the simultaneous evaluation of the in vitro release and permeation of oral solid pharmaceutical dosage forms. The release rate in both dissolution devices (USP and F-C-SL apparatus) was evaluated with acetaminophen tablets. Different test conditions (stirring rate and solvent volume ratio) were investigated and no significant differences in acetaminophen release rate were found between these apparatuses. In the F-C-SL apparatus, the in vitro permeation kinetics of acetaminophen were evaluated using synthetic membranes and followed a zero-order kinetic.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6