Enhancing proteasome-inhibitor effect by functionalized gold nanoparticles

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Silvia Castro Coelho (Author) FEUP; Sandra Rocha (Author) FEUP; Maria do Carmo Pereira (Author) FEUP; Petras Juzenas (Author) Other; Manuel A. N. Coelho (Author) FEUP

Journal

Title: Journal of Biomedical Nanotechnology

Vol. 10 No. 5

Pages: 717-723

ISSN: 1550-7033

Publisher: American Scientific Publishers

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 14 Citations

Associated Projects

BIONANO - Distibuição de biomoleculas através de nanopartículas inorganica/organicas

Other information

Authenticus ID: P-009-CQY

DOI: 10.1166/jbn.2014.1743

Abstract (EN): Colloidal gold nanoparticles intensify the anticancer response of the drug bortezomib, a proteasome inhibitor. Polyethylene glycol-coated gold nanoparticles and the drug show a synergistic effect in reducing the cell viability of prostate cancer cell line Du145. It was observed a significant cell viability reduction with bortezomib concentrations as low as 4 nM. The proteasome inhibitor alone had to be present at concentrations in the ranger of 120 nM to induce identical cytotoxicity response. These findings demonstrate that gold nanoparticles enhancing the permeation and retention (EPR) effect in Du145 cells and open the possibility to decrease multi-drug resistance (MDR). The in vitro results of functionalized gold nanoparticles, internalized by cancer cells, pave the way for a more efficient proteasome inhibitor delivery and release in adenocarcinoma cells. Copyright

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7