Go to:
Logótipo
Comuta visibilidade da coluna esquerda
Você está em: Start > Publications > View > Enhancing proteasome-inhibitor effect by functionalized gold nanoparticles
Publication

Publications

Enhancing proteasome-inhibitor effect by functionalized gold nanoparticles

Title
Enhancing proteasome-inhibitor effect by functionalized gold nanoparticles
Type
Article in International Scientific Journal
Year
2014
Authors
Silvia Castro Coelho
(Author)
FEUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Sandra Rocha
(Author)
FEUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications Without AUTHENTICUS Without ORCID
Petras Juzenas
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Manuel A. N. Coelho
(Author)
FEUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Journal
Vol. 10 No. 5
Pages: 717-723
ISSN: 1550-7033
Other information
Authenticus ID: P-009-CQY
Abstract (EN): Colloidal gold nanoparticles intensify the anticancer response of the drug bortezomib, a proteasome inhibitor. Polyethylene glycol-coated gold nanoparticles and the drug show a synergistic effect in reducing the cell viability of prostate cancer cell line Du145. It was observed a significant cell viability reduction with bortezomib concentrations as low as 4 nM. The proteasome inhibitor alone had to be present at concentrations in the ranger of 120 nM to induce identical cytotoxicity response. These findings demonstrate that gold nanoparticles enhancing the permeation and retention (EPR) effect in Du145 cells and open the possibility to decrease multi-drug resistance (MDR). The in vitro results of functionalized gold nanoparticles, internalized by cancer cells, pave the way for a more efficient proteasome inhibitor delivery and release in adenocarcinoma cells. Copyright
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 7
Documents
We could not find any documents associated to the publication with allowed access.
Related Publications

Of the same authors

Gold nanoparticle delivery-enhanced proteasome inhibitor effect in adenocarcinoma cells (2013)
Article in International Scientific Journal
Sílvia Castro Coelho; Sandra Rocha; Petras Juzenas; Paula Sampaio; Gabriela M Almeida; Filipe Santos Silva; Maria do Carmo Pereira; Manuel A. N. Coelho

Of the same journal

Non-Biologic Nanodelivery Therapies for Rheumatoid Arthritis (2015)
Another Publication in an International Scientific Journal
Virginia M Gouveia; Sofia A C Costa Lima; Claudia Nunes; Salette Reis
Lipid nanoparticles (SLN (R), NLC (R)) for cutaneous drug delivery: Structure, protection and skin effects (2007)
Another Publication in an International Scientific Journal
Souto, EB; Almeida, AJ; Mueller, RH
A Note on Regulatory Concerns and Toxicity Assessment in Lipid-Based Delivery Systems (LDS) (2009)
Another Publication in an International Scientific Journal
Souto, EB; Martins Lopes, P; Lopes, CM; Gaivao, I; Silva, AM; Guedes Pinto, H
Self-Assembled Mannan Nanogel: Cytocompatibility and Cell Localization (2012)
Article in International Scientific Journal
Silvia A Ferreira; Vera Carvalho; Carla Costa; Joao Paulo Teixeira; Manuel Vilanova; Francisco M Gama

See all (12)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Direito da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-10 at 03:27:32 | Privacy Policy | Personal Data Protection Policy | Whistleblowing