The Familial Counterparts of Follicular Cell-Derived Thyroid Tumors

• Type: Another Publication in an International Scientific Journal
• Date: 2010

Authors

Hugo Prazeres (Author) Other; Joana Torres (Author) Other; Paula Soares (Author) FMUP; Manuel Sobrinho Simoes (Author) FMUP

Journal

Title: International Journal of Surgical Pathology

Vol. 18

Pages: 233-242

ISSN: 1066-8969

Publisher: SAGE

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 3 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-4CD

DOI: 10.1177/1066896910366442

Abstract (EN): The follicular cell-derived thyroid cancers (termed nonmedullary thyroid cancers-NMTCs) occur mostly sporadically, but intriguingly, NMTC has the highest familial risk among all cancer sites. This epidemiological observation is strengthened by the clinical occurrence of NMTC in familial aggregation (FNMTC) and by the detection of chromosomal loci in linkage with the disease phenotype. FNMTC loci have been proposed at 14q, 1q21, 19p13.2, 2q21, 8p23, 8q24, 1q21, and 6q22, but to date, no causative mutations have been linked to FNMTCs. In this review, the authors focus on the clinical, morphological, and molecular aspects that characterize familial tumors. Some morphological patterns may alert for a familial disease. FNMTCs share several of the somatic molecular changes associated with sporadic tumors. New genes affected by somatic changes have been disclosed within regions harboring FNMTC loci.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10