Is BRAF mutation screening useful for preoperative risk stratification in papillary thyroid cancer?

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Paula Soares (Author) FMUP; Manuel Sobrinho Simoes (Author) FMUP

Journal

Title: Future Oncology

Vol. 5

Pages: 1225-1229

ISSN: 1479-6694

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 4 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-003-FB7

DOI: 10.2217/fon.09.81

Abstract (EN): Evaluation of: Xing M, Clark D, Guan H et al.: BRAF mutation testing of thyroid fine-needle aspiration biopsy specimens for preoperative risk stratification in papillary thyroid cancer. J. Clin. Oncol. 27(18), 2977-2982 (2009). Although the majority of patients with papillary thyroid cancer are effectively treated with thyroidectomy and selective use of postoperative (131)I therapy, disease persistence/recurrence can afflict a proportion of patients after the initial treatments, BRAF mutations, present in a large proportion of papillary thyroid cancers, illustrate one of the most impressive examples of phenotype-genotype correlation in human pathology. In this study, the authors propose that preoperative BRAF mutation testing of fine-needle aspiration biopsy specimens provides a novel tool for a preoperative risk stratification strategy for predicting the extent of initial disease and subsequent clinical outcomes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5