Intragenic mutations in thyroid cancer

• Type: Another Publication in an International Scientific Journal
• Date: 2008

Authors

Manuel Sobrinho Simoes (Author) FMUP; Valdemar Maximo (Author) FMUP; Ana Sofia Rocha (Author) Other; Vitor Trovisco (Author) Other; Patricia Castro (Author) FMUP; Ana Preto (Author) Other; Jorge Lima (Author) FMUP; Paula Soares (Author) FMUP

Journal

Title: Endocrinology and Metabolism Clinics of North America

Vol. 37

Pages: 333-+

ISSN: 0889-8529

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 78 Citations

Scopus - 83 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-003-YQM

DOI: 10.1016/j.ecl.2008.02.004

Abstract (EN): The close genotype-phenotype relationship that. characterizes thyroid oncology stimulated the authors to address this article by using a mixed, genetic and phenotypic approach. As such, this article addresses the following aspects of intragenic mutations in thyroid cancer: thyroid stimulating hormone receptor and guanine-nucleotide-binding proteins of the stimulatory family mutations in hyperfunctioning tumors; mutations in RAS and other genes and aneuploidy; PAX8-PPAR gamma rearrangements; BRAF mutations; mutations in oxidative phosphorylation and Krebs cycle genes in Hurthle cell tumors; mutations in succinate dehydrogenase genes in medullary carcinoma and C-cell hyperplasia; and mutations in TP53 and other genes in poorly differentiated and anaplastic carcinomas.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 31