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A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway
Title
A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway
Type
Article in International Scientific Journal
Year
2013
Authors
francisco, t
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rodrigues, ta
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freitas, mo
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grou, cp
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carvalho, af
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sá-miranda, c
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pinto, mp
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azevedo, je
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Authenticus ID:
P-008-ESC
Abstract (EN):
Background:How the soluble receptor PEX5 delivers its cargoes to the peroxisome remains largely unknown. Results:Cargo translocation occurs after docking of the receptor at the peroxisome and before any ATP-dependent step. Conclusion:Translocation is concomitant with PEX5 insertion into the docking/translocation machinery. Significance:These results support a model in which cargoes are pushed across the peroxisomal membrane by PEX5. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Language:
English
Type (Professor's evaluation):
Scientific
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