Identification of a 24 kDa intrinsic membrane protein from mammalian peroxisomes

• Type: Article in International Scientific Journal
• Date: 1999

Authors

reguenga, c (Author) Other; oliveira, mem (Author) Other; gouveia, amm (Author) Other; eckerskorn, c (Author) Other; sa-miranda, c (Author) Other; azevedo, je (Author) ICBAS

Journal

Title: Biochimica et Biophysica Acta - Gene Structure and Expression

Vol. 1445

Pages: 337-341

ISSN: 0167-4781

Publisher: Elsevier B.V.

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 22 Citations

Other information

Authenticus ID: P-001-42S

DOI: 10.1016/s0167-4781(99)00061-5

Abstract (EN): A 24 kDa protein from rat liver peroxisomal membrane was isolated and subjected to Edman degradation. Using the N-terminal sequence of this polypeptide we have identified several rat and human expressed sequence tags in the GenBank Database. The complete sequence of a human cDNA clone was determined, The open reading frame encodes an extremely basic protein 212 amino acid residues long. A high similarity between this mammalian protein and hypothetical proteins from Caenorhabditis elegans and Neurospora crassa was found. Hydropathy analysis reveals the existence of two putative membrane-spanning domains in conserved regions of the three homologous proteins.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5