Development and characterization of novel alginate-based hydrogels as vehicles for bone substitutes

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Morais, DS (Author) Other; Rodrigues, MA (Author) Other; Silva, TI (Author) Other; Lopes, MA (Author) FEUP; Santos, M (Author) Other; Santos, JD (Author) FEUP; Botelho, CM (Author) Other

Journal

Title: Carbohydrate Polymers

Vol. 95

Pages: 134-142

ISSN: 0144-8617

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 29 Citations

ISI Web of Science

Scopus - 39 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Technological sciences > Engineering > Biomaterial engineering

Other information

Authenticus ID: P-005-0T4

DOI: 10.1016/j.carbpol.2013.02.067

Abstract (EN): In this work three different hydrogels were developed to associate, as vehicles, with the synthetic bone substitute GR-HAP. One based on an alginate matrix (Alg); a second on a mixture of alginate and chitosan (Alg/Ch); and a third on alginate and hyaluronate (Alg/HA), using Ca2+ ions as cross-linking agents. The hydrogels, as well as the respective injectable bone substitutes (IBSs), were fully characterized from the physical-chemical point of view. Weight change studies proved that all hydrogels were able to swell and degrade within 72 h at pH 7.4 and 4.0, being Alg/HA the hydrogel with the highest degradation rate (80%). Rheology studies demonstrated that all hydrogels are non-Newtonian viscoelastic fluids, and injectability tests showed that IBSs presented low maximum extrusion forces, as well as quite stable average forces. In conclusion, the studied hydrogels present the necessary features to be successfully used as vehicles of GR-HAP, particularly the hydrogel Alg/HA.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9