Electrochemical Study of the Anticancer Drug Daunorubicin at a Water/Oil Interface: Drug Lipophilicity and Quantification

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Jose A Ribeiro (Author) Other; Silva, F (Author) FCUP; Carlos M Pereira (Author) FCUP

Journal

Title: Analytical Chemistry

Vol. 85

Pages: 1582-1590

ISSN: 0003-2700

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 58 Citations

Scopus - 60 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-002-0JG

DOI: 10.1021/ac3028245

Abstract (EN): In this work, the ion transfer mechanism of the anticancer drug daunorubicin (DNR) at a liquid/liquid interface has been studied for the first time. This study was carried out using electrochemical techniques, namely cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The lipophilicity of DNR was investigated at the water/1,6-dichlorohexane (DCH) interface, and the results obtained were presented in the form of an ionic partition diagram. The partition coefficients of both neutral and ionic forms of the drug were determined. The analytical parameter for the detection of DNR was also investigated in this work. An electrochemical DNR sensor is proposed by means of simple ion transfer at the water/DCH interface, using DPV as the quantification technique. Experimental conditions for the analytical determination of DNR were established, and a detection limit of 0.80 mu M was obtained.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9