Substituted Pyrazolo[3,4- d ]pyrimidines: Microwave-Assisted, Solvent-Free Synthesis and Biological Evaluation

• Type: Article in International Scientific Journal
• Date: 2008

Authors

oliveira-campos, amf (Author) Other; sivasubramanian, a (Author) Other; rodrigues, lm (Author) Other; seijas, ja (Author) Other; vazquez-tato, mp (Author) Other; peixoto, f (Author) Other; abreu, cg (Author) Other; cidade, h (Author) FFUP; oliveira, ae (Author) Other; pinto, m (Author) FFUP

Journal

Title: Helvetica Chimica Acta

Vol. 91 No. 7

Pages: 1336-1345

ISSN: 0018-019X

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 16 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-00G-YK8

DOI: 10.1002/hlca.200890145

Abstract (EN): A simple and efficient method has been developed for the synthesis of various pyrazolo[3,4-d]pyrimidines by using microwave irradiation under solvent-free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and, in two cases, by X-ray analysis. The compounds did not display appreciable ability to inhibit xanthine oxidase activity. Screening for antifungal activity showed that some derivatives were active against four fungi, with more significant results for Botrytis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10