Prenylated xanthones: antiproliferative effects and enhancement of the growth inhibitory action of 4-hydroxytamoxifen in estrogen receptor-positive breast cancer cell line

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Ana Mafalda Paiva (Author) Other; Maria Emilia Sousa (Author) FFUP; Ana Camoes (Author) Other; Maria Sao J Jose Nascimento (Author) FFUP; Madalena Maria M Magalhaes Pinto (Author) FFUP

Journal

Title: Medicinal Chemistry Research

Vol. 21

Pages: 552-558

ISSN: 1054-2523

Publisher: Springer Nature

Indexing

ISI Proceedings

ISI Web of Knowledge - 20 Citations

Scopus - 20 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-002-AMD

DOI: 10.1007/s00044-011-9562-z

Abstract (EN): The effects of three prenylated xanthones on the in vitro growth of estrogen-dependent ER (+) MCF-7 (breast), estrogen-independent ER (-) MDA-MB-231 cells (breast), and NCI-H460 (non-small cell lung) were investigated in a complete and/or steroid-free medium. 3,4-Dihydro-12-hydroxy-2,2-dimethyl-2H, 6H-pyrano[3,2-b]xanthen-6-one (4), the most potent against the ER(+) MCF-7 cell line (GI(50) = 5 mu M), showed an enhancement in the anti-estrogenic effect of 4-hydroxytamoxifen in this ER(+) cell line.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7