Hemisynthetic secofriedelane triterpenes with inhibitory activity against the growth of human tumor cell lines in vitro

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Moiteiro, C (Author) Other; Manta, C (Author) Other; Justino, F (Author) Other; Tavares, R (Author) Other; Curto, MJM (Author) Other; Pedro, M (Author) Other; Nascimento, MSJ (Author) FFUP; Pinto, M (Author) FFUP

Journal

Title: Journal of Natural Products

Vol. 67

Pages: 1193-1196

ISSN: 0163-3864

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 18 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-9S3

DOI: 10.1021/np0498915

Abstract (EN): Seco acids 7 and 9 and hydroxylated analogues 5 and 6 derived from friedelane triterpenes were synthesized stereoselectively in high yields. Compounds 5-9 were evaluated for their ability to inhibit in vitro the growth of three human tumor cell lines, MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer). Only compounds 7 and 9 were found to possess significant growth inhibitory effects, exhibiting GI(50) values that range from 24.6 to 32.8 muM and 10.9 to 17.6 muM, respectively.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4